You would be surprised, that there isn’t really a bunch of games that have anything to do with Thanksgiving. That could be due to Thanksgiving is a United States national holiday. So it can be very hard to even find a game with DLC that has something to do with Thanksgiving.
The game that I’ve found to have something to with Thanksgiving is Borderlands 2. Unfortunately, Borderlands 2 doesn’t have anything to do with Thanksgiving unless you buy the DLC for $2.99 on Steam. Which isn’t a bad deal because, you get about 2-3 hours long of straight missions and side quests. Also you get a TON of new guns too!
If you would like to see some gameplay of “The Horrible Hunger of the Ravenous Wattle Gobbler” I’ve provided this link so you can watch some gameplay of it.
Overall, I totally recommend you checking this out and maybe inviting your family to have some fun playing this amazing, horrible, gobbler, massive, giant, Borderlands 2 DLC. (See what I did there?)